Rebuilding the Iron Cage: Post-Failure Organizing in Newspapers and Investment Banks

Organizational failure is an incomplete process because routines and norms persist through employee careers. Qualitative interviews with former employees from four newspapers and two investment banks, all of which are bankrupt or disbanded, demonstrate ongoing utilization of routines and ongoing compliance to norms despite severed connections to the failed firm. Routines are most likely to persist when they relate to low-volatility processes that do not require maintenance to ensure ongoing accessibility. Characteristics that make norms transferable are also identified. Adherence to aesthetic and pragmatic norms depends on how well they fit into new occupational contexts: uptake varies in proportion to the similarity between the failed firm and the new occupational setting of a failure survivor. Justice-oriented norms are not context-dependent; they persist regardless of post-failure employment outcomes. In fact, justice-oriented norms are found to drive the selection of new occupations as journalists seek normative consistency in their careers and some investment bankers change careers to reclaim a sense of purpose lost in banking. These observations hold whether survivors find employment in incumbent firms, entrepreneurial projects, or as freelancers. As survivors adapt work practices, their efforts constitute a form of inter-organizational innovation that generates organizational heterogeneity within unstable industries. Post-failure continuity provides an important and largely undocumented mechanism for the preservation of organizational attributes and the diversification of organizational form amidst crisis, an adaptive process that reconsiders the normative environment of a business and selectively discards assumptions about how firms ought to be. Survivors of failure often face a dilemma in deciding whether to attempt to re-create an occupational setting similar to the firm that failed or to go a different direction. This work takes up this dilemma, asking what insight business ethics research can provide for those who might wonder about the purpose of their firms. A theory of property is used to articulate a normative argument: firms should fail when they are unable to cover their debts and externalities, and firms should survive when they generate surplus value. The dissertation contributes to organizational theories of evolution, to the study of career trajectories, and to a life-cycle approach to business ethics

Tomographic Magnification of Lyman Break Galaxies in The Deep Lens Survey

Using about 450,000 galaxies in the Deep Lens Survey, we present a detection of the gravitational magnification of z > 4 Lyman Break Galaxies by massive foreground galaxies with 0.4 < z < 1.0, grouped by redshift. The magnification signal is detected at S/N greater than 20, and rigorous checks confirm that it is not contaminated by any galaxy sample overlap in redshift. The inferred galaxy mass profiles are consistent with earlier lensing analyses at lower redshift. We then explore the tomographic lens magnification signal by splitting our foreground galaxy sample into 7 redshift bins. Combining galaxy-magnification cross-correlations and galaxy angular auto-correlations, we develop a bias-independent estimator of the tomographic signal. As a diagnostic of magnification tomography, the measurement of this estimator rejects a flat dark matter dominated Universe at > 7.5{\sigma} with a fixed \sigma_8 and is found to be consistent with the expected redshift-dependence of the WMAP7 {\Lambda}CDM cosmology.Comment: 12 pages, 9 figures, Accepted to MNRA

Arc-continent collision: The making of an orogen

Peer Reviewe

The Star Formation Rate Density and Dust Attenuation Evolution over 12 Gyr with the VVDS Surveys

[Abridged] We investigate the global galaxy evolution over 12 Gyr (0.05<z<4.5), from the star formation rate density (SFRD), combining the VVDS Deep (17.5<=I<=24.0) and Ultra-Deep (23.00<=i<=24.75) surveys. We obtain a single homogeneous spectroscopic redshift sample, totalizing about 11000 galaxies. We estimate the rest-frame FUV luminosity function (LF) and luminosity density (LD), extract the dust attenuation of the FUV radiation using SED fitting, and derive the dust-corrected SFRD. We find a constant and flat faint-end slope alpha in the FUV LF at z1.7, we set alpha steepening with (1+z). The absolute magnitude M*_FUV brightens in the entire range 02 it is on average brighter than in the literature, while phi* is smaller. Our total LD shows a peak at z=2, present also when considering all sources of uncertainty. The SFRD history peaks as well at z=2. It rises by a factor of 6 during 2 Gyr (from z=4.5 to z=2), and then decreases by a factor of 12 during 10 Gyr down to z=0.05. This peak is mainly produced by a similar peak within the population of galaxies with -21.5<=M_FUV<=-19.5 mag. As times goes by, the total SFRD is dominated by fainter and fainter galaxies. The presence of a clear peak at z=2 and a fast rise at z>2 of the SFRD is compelling for models of galaxy formation. The mean dust attenuation A_FUV of the global galaxy population rises by 1 mag during 2 Gyr from z=4.5 to z=2, reaches its maximum at z=1 (A_FUV=2.2 mag), and then decreases by 1.1 mag during 7 Gyr down to z=0. The dust attenuation maximum is reached 2 Gyr after the SFRD peak, implying a contribution from the intermediate-mass stars to the dust production at z<2.Comment: 23 pages, 15 figures, accepted for publication in A&

Inhibition of Dipeptidyl Peptidase-4 by Vildagliptin During Glucagon-Like Peptide 1 Infusion Increases Liver Glucose Uptake in the Conscious Dog

OBJECTIVE—This study investigated the acute effects of treatment with vildagliptin on dipeptidyl peptidase-4 (DPP-4) activity, glucagon-like peptide 1 (GLP-1) concentration, pancreatic hormone levels, and glucose metabolism. The primary aims were to determine the effects of DPP-4 inhibition on GLP-1 clearance and on hepatic glucose uptake

Liquid–liquid phase separation morphologies in ultra-white beetle scales and a synthetic equivalent

Cyphochilus beetle scales are amongst the brightest structural whites in nature, being highly opacifying whilst extremely thin. However, the formation mechanism for the voided intra-scale structure is unknown. Here we report 3D x-ray nanotomography data for the voided chitin networks of intact white scales of Cyphochilus and Lepidiota stigma. Chitin-filling fractions are found to be 31 ± 2% for Cyphochilus and 34 ± 1% for Lepidiota stigma, indicating previous measurements overestimated their density. Optical simulations using finite-difference time domain for the chitin morphologies and simulated Cahn-Hilliard spinodal structures show excellent agreement. Reflectance curves spanning filling fraction of 5-95% for simulated spinodal structures, pinpoint optimal whiteness for 25% chitin filling. We make a simulacrum from a polymer undergoing a strong solvent quench, resulting in highly reflective (~94%) white films. In-situ X-ray scattering confirms the nanostructure is formed through spinodal decomposition phase separation. We conclude that the ultra-white beetle scale nanostructure is made via liquid–liquid phase separation

Maternal prepregnancy body mass index and offspring white matter microstructure: results from three birth cohorts

Prepregnancy maternal obesity is a global health problem and has been associated with offspring metabolic and mental ill-health. However, there is a knowledge gap in understanding potential neurobiological factors related to these associations. This study explored the relation between maternal prepregnancy body mass index (BMI) and offspring brain white matter microstructure at the age of 6, 10, and 26 years in three independent cohorts. Maternal BMI was associated with higher FA and lower MD in multiple brain tracts in offspring aged 10 and 26 years, but not at 6 years of age. Future studies should examine whether our observations can be replicated and explore the potential causal nature of the findings.This work was supported by the European Union’s Horizon 2020 research and innovation program [grant agreement no. 633595 DynaHEALTH] and no. 733206 LifeCycle], the Netherlands Organization for Health Research and Development [ZONMW Vici project 016.VICI.170.200]. The PREOBE cohort was funded by Spanish Ministry of Innovation and Science. Junta de Andalucía: Excellence Projects (P06-CTS-02341) and Spanish Ministry of Economy and Competitiveness (BFU2012-40254-C03-01). The first phase of the Generation R Study is made possible by financial support from the Erasmus Medical Centre, the Erasmus University, and the Netherlands Organization for Health Research and Development (ZonMW, grant ZonMW Geestkracht 10.000.1003). The Northern Finland Birth Cohort 1986 is funded by University of Oulu, University Hospital of Oulu, Academy of Finland (EGEA), Sigrid Juselius Foundation, European Commission (EURO-BLCS, Framework 5 award QLG1-CT-2000-01643), NIH/NIMH (5R01MH63706:02

Impact of renal impairment on atrial fibrillation: ESC-EHRA EORP-AF Long-Term General Registry

Background: Atrial fibrillation (AF) and renal impairment share a bidirectional relationship with important pathophysiological interactions. We evaluated the impact of renal impairment in a contemporary cohort of patients with AF. Methods: We utilised the ESC-EHRA EORP-AF Long-Term General Registry. Outcomes were analysed according to renal function by CKD-EPI equation. The primary endpoint was a composite of thromboembolism, major bleeding, acute coronary syndrome and all-cause death. Secondary endpoints were each of these separately including ischaemic stroke, haemorrhagic event, intracranial haemorrhage, cardiovascular death and hospital admission. Results: A total of 9306 patients were included. The distribution of patients with no, mild, moderate and severe renal impairment at baseline were 16.9%, 49.3%, 30% and 3.8%, respectively. AF patients with impaired renal function were older, more likely to be females, had worse cardiac imaging parameters and multiple comorbidities. Among patients with an indication for anticoagulation, prescription of these agents was reduced in those with severe renal impairment, p&nbsp;&lt;.001. Over 24&nbsp;months, impaired renal function was associated with significantly greater incidence of the primary composite outcome and all secondary outcomes. Multivariable Cox regression analysis demonstrated an inverse relationship between eGFR and the primary outcome (HR 1.07 [95% CI, 1.01–1.14] per 10&nbsp;ml/min/1.73&nbsp;m2 decrease), that was most notable in patients with eGFR &lt;30&nbsp;ml/min/1.73&nbsp;m2 (HR 2.21 [95% CI, 1.23–3.99] compared to eGFR ≥90&nbsp;ml/min/1.73&nbsp;m2). Conclusion: A significant proportion of patients with AF suffer from concomitant renal impairment which impacts their overall management. Furthermore, renal impairment is an independent predictor of major adverse events including thromboembolism, major bleeding, acute coronary syndrome and all-cause death in patients with AF

Clinical complexity and impact of the ABC (Atrial fibrillation Better Care) pathway in patients with atrial fibrillation: a report from the ESC-EHRA EURObservational Research Programme in AF General Long-Term Registry

Background: Clinical complexity is increasingly prevalent among patients with atrial fibrillation (AF). The ‘Atrial fibrillation Better Care’ (ABC) pathway approach has been proposed to streamline a more holistic and integrated approach to AF care; however, there are limited data on its usefulness among clinically complex patients. We aim to determine the impact of ABC pathway in a contemporary cohort of clinically complex AF patients. Methods: From the ESC-EHRA EORP-AF General Long-Term Registry, we analysed clinically complex AF patients, defined as the presence of frailty, multimorbidity and/or polypharmacy. A K-medoids cluster analysis was performed to identify different groups of clinical complexity. The impact of an ABC-adherent approach on major outcomes was analysed through Cox-regression analyses and delay of event (DoE) analyses. Results: Among 9966 AF patients included, 8289 (83.1%) were clinically complex. Adherence to the ABC pathway in the clinically complex group reduced the risk of all-cause death (adjusted HR [aHR]: 0.72, 95%CI 0.58–0.91), major adverse cardiovascular events (MACEs; aHR: 0.68, 95%CI 0.52–0.87) and composite outcome (aHR: 0.70, 95%CI: 0.58–0.85). Adherence to the ABC pathway was associated with a significant reduction in the risk of death (aHR: 0.74, 95%CI 0.56–0.98) and composite outcome (aHR: 0.76, 95%CI 0.60–0.96) also in the high-complexity cluster; similar trends were observed for MACEs. In DoE analyses, an ABC-adherent approach resulted in significant gains in event-free survival for all the outcomes investigated in clinically complex patients. Based on absolute risk reduction at 1 year of follow-up, the number needed to treat for ABC pathway adherence was 24 for all-cause death, 31 for MACEs and 20 for the composite outcome. Conclusions: An ABC-adherent approach reduces the risk of major outcomes in clinically complex AF patients. Ensuring adherence to the ABC pathway is essential to improve clinical outcomes among clinically complex AF patients

Impact of clinical phenotypes on management and outcomes in European atrial fibrillation patients: a report from the ESC-EHRA EURObservational Research Programme in AF (EORP-AF) General Long-Term Registry

Background: Epidemiological studies in atrial fibrillation (AF) illustrate that clinical complexity increase the risk of major adverse outcomes. We aimed to describe European AF patients\u2019 clinical phenotypes and analyse the differential clinical course. Methods: We performed a hierarchical cluster analysis based on Ward\u2019s Method and Squared Euclidean Distance using 22 clinical binary variables, identifying the optimal number of clusters. We investigated differences in clinical management, use of healthcare resources and outcomes in a cohort of European AF patients from a Europe-wide observational registry. Results: A total of 9363 were available for this analysis. We identified three clusters: Cluster 1 (n = 3634; 38.8%) characterized by older patients and prevalent non-cardiac comorbidities; Cluster 2 (n = 2774; 29.6%) characterized by younger patients with low prevalence of comorbidities; Cluster 3 (n = 2955;31.6%) characterized by patients\u2019 prevalent cardiovascular risk factors/comorbidities. Over a mean follow-up of 22.5 months, Cluster 3 had the highest rate of cardiovascular events, all-cause death, and the composite outcome (combining the previous two) compared to Cluster 1 and Cluster 2 (all P &lt;.001). An adjusted Cox regression showed that compared to Cluster 2, Cluster 3 (hazard ratio (HR) 2.87, 95% confidence interval (CI) 2.27\u20133.62; HR 3.42, 95%CI 2.72\u20134.31; HR 2.79, 95%CI 2.32\u20133.35), and Cluster 1 (HR 1.88, 95%CI 1.48\u20132.38; HR 2.50, 95%CI 1.98\u20133.15; HR 2.09, 95%CI 1.74\u20132.51) reported a higher risk for the three outcomes respectively. Conclusions: In European AF patients, three main clusters were identified, differentiated by differential presence of comorbidities. Both non-cardiac and cardiac comorbidities clusters were found to be associated with an increased risk of major adverse outcomes